Single‐centre experience of implementing physiotherapist‐led prehabilitation for chimeric antigen receptor T cell therapy

Abstract

Abstract Introduction This report outlines the evaluation of physiotherapist‐led prehabilitation/rehabilitation for recipients of chimeric antigen receptor T (CAR‐T) cell therapy. Methods A hybrid approach was used, incorporating in‐person assessment of quality of life and functional capacity (6‐min walk test and timed sit‐to‐stand test), and a personalised home exercise programme with remotely delivered physiotherapist support pre/post‐admission. Results Functional deficits were prevalent at referral for CAR‐T. Prehabilitation and rehabilitation were highly acceptable to patients, and improvements in functional capacity were documented pre‐admission. Conclusion This data highlights the importance of pre‐CAR‐T functional assessment and prehabilitation to optimise preparation and recovery.

Keywords

• chimeric antigen receptor T‐cell therapy
• exercise
• physiotherapy
• rehabilitation