Circulating level of 25(OH)D3 with risk factors of asymptomatic adenoma and proximal non-adenoma colorectal polyps

Abstract

Background: An inverse association between circulating vitamin D and adenoma risk has been reported, but less is known about proximal inflammatory-hyperplastic polyps. Purpose: To investigate circulating 25(OH)D3 and risk factors of proximal inflammatory-hyperplastic and adenoma colorectal polyps. Methods: From January 2017 to June 2019, consecutive asymptomatic average-risk participants undergoing initial screening colonoscopy. Questionnaires provided information on colorectal polyp risk factors, and plasma samples were assayed for 25-Hydroxyvitamin-D ‒ 25(OH)D3. The colorectal polyps were assessed, and medical history and demographic data were obtained from each patient. Results: Of the 220 asymptomatic subjects, the prevalence of proximal inflammatory-hyperplastic polyps and adenoma polyps were 16.8%; 18.1% and 22.2%, respectively. Multivariate analysis revealed that low vitamin D (25(OH)D3 24, OR = 5.32, 95% CI: 2.62–4.71) were independent predictors for proximal inflammatory-hyperplastic colorectal polyps (non-adenoma). Low vitamin D (25(OH)D3 24, OR = 5,32, IC 95%: 2,62–4,71) foram preditivos independentes para pólipos colorretais hiperplásico-inflamatórios proximais (não adenomatosos). Nível baixo de vitamina D (25(OH)D3 < 18 ng/mL, OR = 7,75; IC 95%: 3,19–18,80), tabagismo atual/anterior (OR = 3,75; IC 95%: 1,30–10,81) e idade acima de 60 anos (OR = 2,38, IC 95%: 1,02–5,57) foram preditivos independentes para pólipos colorretais adenomatosos. Conclusão: Nível baixo de vitamina D e tabagismo são fatores de risco comuns para pólipos tanto adenomatosos quanto hiperplásico-inflamatórios proximais. Idade avançada e IMC são fatores de risco adicionais para o desenvolvimento de pólipos colorretais adenomatosos e não adenomatosos.

Keywords

• 25(OH)D3 circulante
• Fatores de risco
• Adenoma
• Pólipo proximal
• Assintomático