Unraveling the hidden temporal range of fast β2-adrenergic receptor mobility by time-resolved fluorescence

Ashwin Balakrishnan; Katherina Hemmen; Susobhan Choudhury; Jan-Hagen Krohn; Kerstin Jansen; Mike Friedrich; Gerti Beliu; Markus Sauer; Martin J. Lohse; Katrin G. Heinze

doi:10.1038/s42003-022-03106-4

Communications Biology (Feb 2022)

Unraveling the hidden temporal range of fast β2-adrenergic receptor mobility by time-resolved fluorescence

Ashwin Balakrishnan,
Katherina Hemmen,
Susobhan Choudhury,
Jan-Hagen Krohn,
Kerstin Jansen,
Mike Friedrich,
Gerti Beliu,
Markus Sauer,
Martin J. Lohse,
Katrin G. Heinze

Affiliations

Ashwin Balakrishnan: Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
Katherina Hemmen: Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
Susobhan Choudhury: Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
Jan-Hagen Krohn: Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
Kerstin Jansen: Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
Mike Friedrich: Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
Gerti Beliu: Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
Markus Sauer: Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
Martin J. Lohse: Max Delbrück Center for Molecular Medicine
Katrin G. Heinze: Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg

DOI: https://doi.org/10.1038/s42003-022-03106-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

Read online

The mobility of the β2-adrenergic receptor, from the nanosecond to the second range, is revealed by combining several fluorescent spectroscopy techniques. These data also show a previously hidden mobility of this GPCR.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal