Journal of Infection and Public Health (Nov 2023)

Significant increase in anti-SARS-CoV-2 antibodies after administration of heterologous mRNA-based vaccine booster in individuals receiving two doses of inactivated COVID-19 vaccine: A single-center study in healthcare workers in Jakarta, Indonesia

  • Wuryantari Setiadi,
  • Qothrunnada Effendi,
  • Edison Johar,
  • Benediktus Yohan,
  • Dhita Prabasari Wibowo,
  • Lepa Syahrani,
  • Alana Arumsari Pramono,
  • Hannie H. Kartapradja,
  • Frilasita Aisyah Yudhaputri,
  • Beti Ernawati Dewi,
  • Safarina G. Malik,
  • Khin Saw Aye Myint,
  • Amin Soebandrio,
  • Dodi Safari

Journal volume & issue
Vol. 16, no. 11
pp. 1848 – 1851

Abstract

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Background: Vaccine plays an important role in breaking SARS-CoV-2 transmission and accelerating the path to pandemic recovery. Currently, there is still limited data on heterologous COVID-19 booster vaccination efficacy and effectiveness in Indonesia. Methods: Antibody response was retrospectively analyzed from 156 serum collected from healthcare workers that have received mRNA-1273 vaccine as the booster against SARS-CoV-2. These individuals had previously received the full two doses of inactivated anti-SARS-CoV-2 vaccine. Serological analysis was performed to measure total antibody, as well as IgA and IgG antibodies specific to spike (S) protein using ECLIA and ELISA methods. Results: A significant increase in total, IgA, and IgG antibody titers was reported in vaccine receiving a third heterologous booster dose of mRNA-based COVID-19 vaccine following two doses of inactivated type. Conclusion: The third heterologous booster dose of vaccine may be beneficial to individuals with or without previous history of SARS-CoV-2 infection.

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