Incidence of Large-for-Gestational Age Newborn among Pregnant Women with One Abnormal Value Oral Glucose Tolerance Test

Abstract

ObjectivesTo evaluate the incidence and risk factors of LGA newborn among pregnant women with one abnormal value OGTT. DesignRetrospective cohort study. MethodsA total of 189 pregnant women who had one abnormal value OGTT were enrolled and followed until delivery. Incidence of LGA was determined as the main outcome. Comparison between LGA and non-LGA was performed with regard to various clinical characteristics to determine associated risk factors. Pregnancy and neonatal outcomes were also evaluated. ResultsIncidence of LGA newborn was 19.05% (36/189 cases). The independent associated factors of LGA newborn was multiparity (adjusted OR 5.3, 95%CI 1.2-23.2, p=0.029) and excessive weight gain (adjusted OR 50.2, 95%CI 12.4-203.9, p <0.001). LGA newborn had significant increased rate of cesarean section (83.3% vs 5.9%, p <0.001) and neonatal hypoglycemia (5.6% vs 0%, p=0.035). ConclusionPregnant women with one abnormal value OGTT who were multiparous or had excessive weight gain had a significant risk of LGA newborn.

Keywords

• one abnormal value oral glucose tolerance test
• large-for-gestational age newborn