Management of Brain Cancer and Neurodegenerative Disorders with Polymer-Based Nanoparticles as a Biocompatible Platform

Mehdi Bazi Alahri; Alhawarin Jibril Ibrahim; Mahmood Barani; Hassan Arkaban; Seyedeh Malahat Shadman; Soodeh Salarpour; Payam Zarrintaj; Javad Jaberi; Abduladheem Turki Jalil

doi:10.3390/molecules28020841

Molecules (Jan 2023)

Management of Brain Cancer and Neurodegenerative Disorders with Polymer-Based Nanoparticles as a Biocompatible Platform

Mehdi Bazi Alahri,
Alhawarin Jibril Ibrahim,
Mahmood Barani,
Hassan Arkaban,
Seyedeh Malahat Shadman,
Soodeh Salarpour,
Payam Zarrintaj,
Javad Jaberi,
Abduladheem Turki Jalil

Affiliations

Mehdi Bazi Alahri: Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1971653313, Iran
Alhawarin Jibril Ibrahim: Department of Chemistry, Faculty of Science, Al-Hussein Bin Talal University, Ma’an 71111, Jordan
Mahmood Barani: Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman 7616913555, Iran
Hassan Arkaban: Department of Chemistry, University of Isfahan, Isfahan 8174673441, Iran
Seyedeh Malahat Shadman: Department of Chemistry, University of Isfahan, Isfahan 8174673441, Iran
Soodeh Salarpour: Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 7616913555, Iran
Payam Zarrintaj: School of Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, OK 74078, USA
Javad Jaberi: Department of Chemistry, University of Isfahan, Isfahan 8174673441, Iran
Abduladheem Turki Jalil: Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla 51001, Iraq

DOI: https://doi.org/10.3390/molecules28020841
Journal volume & issue: Vol. 28, no. 2
p. 841

Abstract

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The blood–brain barrier (BBB) serves as a protective barrier for the central nervous system (CNS) against drugs that enter the bloodstream. The BBB is a key clinical barrier in the treatment of CNS illnesses because it restricts drug entry into the brain. To bypass this barrier and release relevant drugs into the brain matrix, nanotechnology-based delivery systems have been developed. Given the unstable nature of NPs, an appropriate amount of a biocompatible polymer coating on NPs is thought to have a key role in reducing cellular cytotoxicity while also boosting stability. Human serum albumin (HSA), poly (lactic-co-glycolic acid) (PLGA), Polylactide (PLA), poly (alkyl cyanoacrylate) (PACA), gelatin, and chitosan are only a few of the significant polymers mentioned. In this review article, we categorized polymer-coated nanoparticles from basic to complex drug delivery systems and discussed their application as novel drug carriers to the brain.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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