The Green and Efficient One-pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives

Abstract

Glutamic acid is used as an efficient organocatalyst for one-pot synthesis of tetrahydrobenzo [b]pyran via condensation of an aromatic aldehyde, dimedone and malononitrile in ethanol: water (1:4) as solvent at reflux temperature. The short reaction time, cleaner reaction, and easy workup make this protocol practical and economically attractive.

Keywords

• Aldehydes
• Dimedone
• Glutamic acid
• Multicomponent reactions
• Tetrahydrobenzo[b]pyran