GLUCOCORTICOIDS AND ARTERIAL HYPERTENSION IN INTERNAL ORGANS RECIPIENTS

Abstract

In this paper we present a review of literary data about the modem views on glucocorticoid arterial hypertension arrangement in donor organs recipients. Arterial hypertension is one of the main risk, pacing for cardiovascular complications development. In cases with glucocorticoids uptake arterial blood pressure develops approximately in 15–20%. We generalized the main schemes participating in genesis of the arterial hypertension induced by glucocorticoids: a time delay of sodium and increase in circulating liquid volume, GC-dependent vasoconstriction, increased synthesis of catecholamines and beta-1 adrenergic receptor expression, change of noradrenaline sensitivity as a result of the increased endothelin synthesis. In a practical manipulation it is necessary to use non-steroid protocols or minimize doses in internal organs recipients, weighing risks of transplant rejection and possible undesirable side responses in cases with glucocorticoids administration.

Keywords

• transplantation
• arterial hypertension
• glucocorticosteroids