Nature Communications (Mar 2020)
Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
- Qing Ji,
- Lihong Zhou,
- Hua Sui,
- Liu Yang,
- Xinnan Wu,
- Qing Song,
- Ru Jia,
- Ruixiao Li,
- Jian Sun,
- Ziyuan Wang,
- Ningning Liu,
- Yuanyuan Feng,
- Xiaoting Sun,
- Gang Cai,
- Yu Feng,
- Jianfeng Cai,
- Yihai Cao,
- Guoxiang Cai,
- Yan Wang,
- Qi Li
Affiliations
- Qing Ji
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Lihong Zhou
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Hua Sui
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Liu Yang
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Xinnan Wu
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Qing Song
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Ru Jia
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Ruixiao Li
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Jian Sun
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Ziyuan Wang
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Ningning Liu
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Yuanyuan Feng
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Xiaoting Sun
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Gang Cai
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Yu Feng
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Jianfeng Cai
- Department of Chemistry, University of South Florida
- Yihai Cao
- Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine
- Guoxiang Cai
- Department of Colorectal Surgery, Fudan University Shanghai Cancer Center
- Yan Wang
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- Qi Li
- Department of Medical Oncology and cancer institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
- DOI
- https://doi.org/10.1038/s41467-020-14869-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Mechanisms regulating the formation of pre-metastatic niches remain poorly understood. Here, the authors show that ITGBL1-containing extracellular vesicles derived from primary colorectal cancer cells activate the production of inflammatory cytokines by resident fibroblasts in distant organs, promoting metastatic cancer growth.
