Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth

Xiaofan Guo; Yuan Pan; Min Xiong; Shilpa Sanapala; Corina Anastasaki; Olivia Cobb; Sonika Dahiya; David H. Gutmann

doi:10.1038/s41467-020-15770-3

Nature Communications (May 2020)

Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth

Xiaofan Guo,
Yuan Pan,
Min Xiong,
Shilpa Sanapala,
Corina Anastasaki,
Olivia Cobb,
Sonika Dahiya,
David H. Gutmann

Affiliations

Xiaofan Guo: Department of Neurology, Washington University School of Medicine
Yuan Pan: Department of Neurology, Washington University School of Medicine
Min Xiong: Department of Neurology, Washington University School of Medicine
Shilpa Sanapala: Department of Neurology, Washington University School of Medicine
Corina Anastasaki: Department of Neurology, Washington University School of Medicine
Olivia Cobb: Department of Neurology, Washington University School of Medicine
Sonika Dahiya: Department of Pathology, Washington University School of Medicine
David H. Gutmann: Department of Neurology, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-15770-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

The role of neurons and T cells in glioma progression remains poorly understood. Here the authors show that midkine-dependent activation of a neuron-T cell-microglia axis promotes the growth of optic pathway gliomas.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal