Nature Communications (Aug 2019)
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
- Bahareh Eftekharzadeh,
- Varuna C. Banduseela,
- Giulio Chiesa,
- Paula Martínez-Cristóbal,
- Jennifer N. Rauch,
- Samir R. Nath,
- Daniel M. C. Schwarz,
- Hao Shao,
- Marta Marin-Argany,
- Claudio Di Sanza,
- Elisa Giorgetti,
- Zhigang Yu,
- Roberta Pierattelli,
- Isabella C. Felli,
- Isabelle Brun-Heath,
- Jesús García,
- Ángel R. Nebreda,
- Jason E. Gestwicki,
- Andrew P. Lieberman,
- Xavier Salvatella
Affiliations
- Bahareh Eftekharzadeh
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Varuna C. Banduseela
- Department of Pathology, University of Michigan
- Giulio Chiesa
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Paula Martínez-Cristóbal
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Jennifer N. Rauch
- University of California at San Francisco, Department of Pharmaceutical Chemistry
- Samir R. Nath
- Department of Pathology, University of Michigan
- Daniel M. C. Schwarz
- University of California at San Francisco, Department of Pharmaceutical Chemistry
- Hao Shao
- University of California at San Francisco, Department of Pharmaceutical Chemistry
- Marta Marin-Argany
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Claudio Di Sanza
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Elisa Giorgetti
- Department of Pathology, University of Michigan
- Zhigang Yu
- Department of Pathology, University of Michigan
- Roberta Pierattelli
- CERM and Department of Chemistry “Ugo Schiff”, University of Florence
- Isabella C. Felli
- CERM and Department of Chemistry “Ugo Schiff”, University of Florence
- Isabelle Brun-Heath
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Jesús García
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Ángel R. Nebreda
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Jason E. Gestwicki
- University of California at San Francisco, Department of Pharmaceutical Chemistry
- Andrew P. Lieberman
- Department of Pathology, University of Michigan
- Xavier Salvatella
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-019-11594-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Hsp chaperones stabilize the inactive conformation of androgen receptor (AR) and are released upon hormone-induced AR activation. Here, the authors locate the Hsp binding region on AR, and show that Hsp70 reduces AR aggregation and promotes AR degradation in cellular and mouse models of a neuromuscular disorder.
