BMC Medicine (Aug 2020)
Does parity matter in women’s risk of dementia? A COSMIC collaboration cohort study
- Jong Bin Bae,
- Darren M. Lipnicki,
- Ji Won Han,
- Perminder S. Sachdev,
- Tae Hui Kim,
- Kyung Phil Kwak,
- Bong Jo Kim,
- Shin Gyeom Kim,
- Jeong Lan Kim,
- Seok Woo Moon,
- Joon Hyuk Park,
- Seung-Ho Ryu,
- Jong Chul Youn,
- Dong Young Lee,
- Dong Woo Lee,
- Seok Bum Lee,
- Jung Jae Lee,
- Jin Hyeong Jhoo,
- Juan J. Llibre-Rodriguez,
- Jorge J. Llibre-Guerra,
- Adolfo J. Valhuerdi-Cepero,
- Karen Ritchie,
- Marie-Laure Ancelin,
- Isabelle Carriere,
- Ingmar Skoog,
- Jenna Najar,
- Therese Rydberg Sterner,
- Nikolaos Scarmeas,
- Mary Yannakoulia,
- Efthimios Dardiotis,
- Kenichi Meguro,
- Mari Kasai,
- Kei Nakamura,
- Steffi Riedel-Heller,
- Susanne Roehr,
- Alexander Pabst,
- Martin van Boxtel,
- Sebastian Köhler,
- Ding Ding,
- Qianhua Zhao,
- Xiaoniu Liang,
- Marcia Scazufca,
- Antonio Lobo,
- Concepción De-la-Cámara,
- Elena Lobo,
- Ki Woong Kim,
- for Cohort Studies of Memory in an International Consortium (COSMIC)
Affiliations
- Jong Bin Bae
- Department of Neuropsychiatry, Seoul National University Bundang Hospital
- Darren M. Lipnicki
- Centre for Healthy Brain Ageing, University of New South Wales
- Ji Won Han
- Department of Neuropsychiatry, Seoul National University Bundang Hospital
- Perminder S. Sachdev
- Centre for Healthy Brain Ageing, University of New South Wales
- Tae Hui Kim
- Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital
- Kyung Phil Kwak
- Department of Psychiatry, Dongguk University Gyeongju Hospital
- Bong Jo Kim
- Department of Psychiatry, School of Medicine, Gyeongsang National University
- Shin Gyeom Kim
- Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital
- Jeong Lan Kim
- Department of Psychiatry, School of Medicine, Chungnam National University
- Seok Woo Moon
- Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Chungju Hospital
- Joon Hyuk Park
- Department of Neuropsychiatry, Jeju National University Hospital
- Seung-Ho Ryu
- Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Medical Center
- Jong Chul Youn
- Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly
- Dong Young Lee
- Department of Psychiatry, College of Medicine, Seoul National University
- Dong Woo Lee
- Department of Neuropsychiatry, Inje University Sanggye Paik Hospital
- Seok Bum Lee
- Department of Psychiatry, Dankook University Hospital
- Jung Jae Lee
- Department of Psychiatry, Dankook University Hospital
- Jin Hyeong Jhoo
- Department of Neuropsychiatry, Kangwon National University Hospital
- Juan J. Llibre-Rodriguez
- Finlay-Albarrán Faculty of Medical Sciences, Medical University of Havana
- Jorge J. Llibre-Guerra
- Institute of Neurology and Neurosurgery
- Adolfo J. Valhuerdi-Cepero
- Memory and Aging Center, University of California San Francisco
- Karen Ritchie
- Inserm U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital
- Marie-Laure Ancelin
- Inserm U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital
- Isabelle Carriere
- Inserm U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital
- Ingmar Skoog
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience of Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg
- Jenna Najar
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience of Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg
- Therese Rydberg Sterner
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience of Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg
- Nikolaos Scarmeas
- 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School
- Mary Yannakoulia
- Department of Nutrition and Dietetics, Harokopio University
- Efthimios Dardiotis
- Neurology Department, University Hospital of Larissa, University of Thessaly
- Kenichi Meguro
- Geriatric Behavioral Neurology, Tohoku University
- Mari Kasai
- Geriatric Behavioral Neurology, Tohoku University
- Kei Nakamura
- Geriatric Behavioral Neurology, Tohoku University
- Steffi Riedel-Heller
- Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig
- Susanne Roehr
- Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig
- Alexander Pabst
- Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig
- Martin van Boxtel
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University
- Sebastian Köhler
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University
- Ding Ding
- Institute of Neurology, Huashan Hospital, Fudan University
- Qianhua Zhao
- Institute of Neurology, Huashan Hospital, Fudan University
- Xiaoniu Liang
- Institute of Neurology, Huashan Hospital, Fudan University
- Marcia Scazufca
- University of São Paulo
- Antonio Lobo
- Universidad de Zaragoza
- Concepción De-la-Cámara
- Universidad de Zaragoza
- Elena Lobo
- Universidad de Zaragoza
- Ki Woong Kim
- Department of Neuropsychiatry, Seoul National University Bundang Hospital
- for Cohort Studies of Memory in an International Consortium (COSMIC)
- DOI
- https://doi.org/10.1186/s12916-020-01671-1
- Journal volume & issue
-
Vol. 18,
no. 1
pp. 1 – 11
Abstract
Abstract Background Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied. Methods We harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14,792 women aged 60 years or older. We investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype. Results Across all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.10–1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. However, there were differences associated with region and dementia subtype. Compared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in Europe (OR = 2.99, 95% CI = 1.38–6.47) and Latin America (OR = 1.49, 95% CI = 1.04–2.12), while nulliparous women showed a higher dementia risk in Asia (OR = 2.15, 95% CI = 1.33–3.47). Grand multiparity was associated with 6.9-fold higher risk of vascular dementia in Europe (OR = 6.86, 95% CI = 1.81–26.08), whereas nulliparity was associated with a higher risk of Alzheimer disease (OR = 1.91, 95% CI 1.07–3.39) and non-Alzheimer non-vascular dementia (OR = 3.47, 95% CI = 1.44–8.35) in Asia. Conclusion Parity is associated with women’s risk of dementia, though this is not uniform across regions and dementia subtypes.
Keywords
