Mechanism of inducing microglial inflammatory response in patients with depression

Abstract

Microglial inflammatory response is a pathological process frequently found in patients with depression and in animal models, which is believed to be closely related to depression. The potential mechanisms of inducing microglial inflammatory response by depression includes the direct or indirect regulation of glucocorticoid level changes after activation of the hypothalamic-pituitary-adrenal (HPA) axis, the effect of intestinal microbial metabolites through immune and neural pathways in the brain-gut axis, and the direct activation of damage associated molecular patterns (DAMPs) in microglia.

Keywords

• depression|microglial inflammatory response|hypothalamic-pituitary-adrenal (hpa) axis|gut-brain axis|damage associated molecular patterns (damps)