Nature Communications (Sep 2020)
Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
- Jan Krivanek,
- Ruslan A. Soldatov,
- Maria Eleni Kastriti,
- Tatiana Chontorotzea,
- Anna Nele Herdina,
- Julian Petersen,
- Bara Szarowska,
- Marie Landova,
- Veronika Kovar Matejova,
- Lydie Izakovicova Holla,
- Ulrike Kuchler,
- Ivana Vidovic Zdrilic,
- Anushree Vijaykumar,
- Anamaria Balic,
- Pauline Marangoni,
- Ophir D. Klein,
- Vitor C. M. Neves,
- Val Yianni,
- Paul T. Sharpe,
- Tibor Harkany,
- Brian D. Metscher,
- Marc Bajénoff,
- Mina Mina,
- Kaj Fried,
- Peter V. Kharchenko,
- Igor Adameyko
Affiliations
- Jan Krivanek
- Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna
- Ruslan A. Soldatov
- Department of Biomedical Informatics, Harvard Medical School
- Maria Eleni Kastriti
- Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna
- Tatiana Chontorotzea
- Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna
- Anna Nele Herdina
- Department of Physiology and Pharmacology, Karolinska Institutet
- Julian Petersen
- Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna
- Bara Szarowska
- Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna
- Marie Landova
- Institute of Animal Physiology and Genetics, CAS
- Veronika Kovar Matejova
- Clinic of Stomatology, Institution Shared with St. Anne’s Faculty Hospital, Faculty of Medicine, Masaryk University
- Lydie Izakovicova Holla
- Clinic of Stomatology, Institution Shared with St. Anne’s Faculty Hospital, Faculty of Medicine, Masaryk University
- Ulrike Kuchler
- Department of Oral Biology, Medical University of Vienna
- Ivana Vidovic Zdrilic
- Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center
- Anushree Vijaykumar
- Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center
- Anamaria Balic
- Research Program in Developmental Biology, Institute of Biotechnology, University of Helsinki
- Pauline Marangoni
- Program in Craniofacial Biology and Department of Orofacial Sciences, University of California
- Ophir D. Klein
- Program in Craniofacial Biology and Department of Orofacial Sciences, University of California
- Vitor C. M. Neves
- Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences. King’s College London
- Val Yianni
- Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences. King’s College London
- Paul T. Sharpe
- Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences. King’s College London
- Tibor Harkany
- Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna
- Brian D. Metscher
- Department of Evolutionary Biology, University of Vienna
- Marc Bajénoff
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS UMR
- Mina Mina
- Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center
- Kaj Fried
- Department of Neuroscience, Karolinska Institutet
- Peter V. Kharchenko
- Department of Biomedical Informatics, Harvard Medical School
- Igor Adameyko
- Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s41467-020-18512-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combined with lineage tracing to reveal dental cell complexity.
