Frontiers in Immunology (Aug 2021)
Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
- Berislav Bošnjak,
- Ivan Odak,
- Christiane Ritter,
- Klaus Stahl,
- Theresa Graalmann,
- Theresa Graalmann,
- Lars Steinbrück,
- Rainer Blasczyk,
- Christine S. Falk,
- Christine S. Falk,
- Thomas F. Schulz,
- Thomas F. Schulz,
- Thomas F. Schulz,
- Hans Heinrich Wedemeyer,
- Hans Heinrich Wedemeyer,
- Hans Heinrich Wedemeyer,
- Markus Cornberg,
- Markus Cornberg,
- Markus Cornberg,
- Arnold Ganser,
- Reinhold Förster,
- Reinhold Förster,
- Christian Koenecke,
- Christian Koenecke,
- Christian Koenecke
Affiliations
- Berislav Bošnjak
- Institute of Immunology, Hannover Medical School, Hannover, Germany
- Ivan Odak
- Institute of Immunology, Hannover Medical School, Hannover, Germany
- Christiane Ritter
- Institute of Immunology, Hannover Medical School, Hannover, Germany
- Klaus Stahl
- Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
- Theresa Graalmann
- Department of Rheumatology and Clinical Immunology, Hannover Medical School, Hannover, Germany
- Theresa Graalmann
- TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany
- Lars Steinbrück
- Institute of Virology, Hannover Medical School, Hannover, Germany
- Rainer Blasczyk
- Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany
- Christine S. Falk
- Institute of Transplantation Immunology, Hannover Medical School, Hannover, Germany
- Christine S. Falk
- German Center for Infection Research (DZIF), Partner Site, Hannover-Braunschweig, Germany
- Thomas F. Schulz
- Institute of Virology, Hannover Medical School, Hannover, Germany
- Thomas F. Schulz
- German Center for Infection Research (DZIF), Partner Site, Hannover-Braunschweig, Germany
- Thomas F. Schulz
- Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany
- Hans Heinrich Wedemeyer
- Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
- Hans Heinrich Wedemeyer
- Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany
- Hans Heinrich Wedemeyer
- 0Centre for Individualized Infection Medicine (CiiM) , Hannover, Germany
- Markus Cornberg
- Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
- Markus Cornberg
- Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany
- Markus Cornberg
- 0Centre for Individualized Infection Medicine (CiiM) , Hannover, Germany
- Arnold Ganser
- 1Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
- Reinhold Förster
- Institute of Immunology, Hannover Medical School, Hannover, Germany
- Reinhold Förster
- Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany
- Christian Koenecke
- Institute of Immunology, Hannover Medical School, Hannover, Germany
- Christian Koenecke
- 0Centre for Individualized Infection Medicine (CiiM) , Hannover, Germany
- Christian Koenecke
- 1Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
- DOI
- https://doi.org/10.3389/fimmu.2021.721738
- Journal volume & issue
-
Vol. 12
Abstract
Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.
Keywords
