Nature Communications (Jun 2017)
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
- A. S. Axelsson,
- T. Mahdi,
- H. A. Nenonen,
- T. Singh,
- S. Hänzelmann,
- A. Wendt,
- A. Bagge,
- T. M. Reinbothe,
- J. Millstein,
- X. Yang,
- B. Zhang,
- E. G. Gusmao,
- L. Shu,
- M. Szabat,
- Y. Tang,
- J. Wang,
- S. Salö,
- L. Eliasson,
- I. Artner,
- M. Fex,
- J. D. Johnson,
- C. B. Wollheim,
- J.M.J. Derry,
- B. Mecham,
- P. Spégel,
- H. Mulder,
- I.G. Costa,
- E. Zhang,
- A. H. Rosengren
Affiliations
- A. S. Axelsson
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- T. Mahdi
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- H. A. Nenonen
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- T. Singh
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- S. Hänzelmann
- Institute of Biomedical Engineering, RWTH Aachen University Hospital
- A. Wendt
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- A. Bagge
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- T. M. Reinbothe
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- J. Millstein
- Sage Bionetworks
- X. Yang
- Sage Bionetworks
- B. Zhang
- Sage Bionetworks
- E. G. Gusmao
- Institute of Biomedical Engineering, RWTH Aachen University Hospital
- L. Shu
- Department of Integrative Biology and Physiology, University of California
- M. Szabat
- Department of Cellular and Physiological Sciences, Diabetes Research Group, Life Sciences Institute, University of British Columbia
- Y. Tang
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- J. Wang
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- S. Salö
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- L. Eliasson
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- I. Artner
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- M. Fex
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- J. D. Johnson
- Department of Cellular and Physiological Sciences, Diabetes Research Group, Life Sciences Institute, University of British Columbia
- C. B. Wollheim
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- J.M.J. Derry
- Sage Bionetworks
- B. Mecham
- Trialomics
- P. Spégel
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- H. Mulder
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- I.G. Costa
- Institute of Biomedical Engineering, RWTH Aachen University Hospital
- E. Zhang
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- A. H. Rosengren
- Lund University Diabetes Center, CRC 91-11 SUS, Jan Waldenströms gata 35
- DOI
- https://doi.org/10.1038/ncomms15652
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Type 2 diabetes (T2D) is a heterogeneous disorder characterized by insulin resistance and impaired insulin secretion. Here Axelssonet al. show that Sox5, which is reduced in diabetes, regulates a set of differentially expressed genes in T2D and its genetic and pharmacological induction improves insulin secretion by diabetic islets.
