The Chemistry and Biology of Cyclophostin, the Cyclipostins and Related Compounds

Abstract

Cyclophostin, the cyclipostins and the salinipostins are structurally related cyclic enolphosphate natural products. This mini review describes their isolation, synthesis and biological activities. In addition, the synthesis and biological activities of monocyclic enolphosphate and mono and bicyclic enolphosphonate analogs are presented.

Keywords

• cyclophostin
• cyclipostins
• enolphosphate
• enolphosphonate
• bicyclic
• monocyclic
• lipase
• inhibitor