Nature Communications (Mar 2022)
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Nanda Horeweg,
- Hagma H. Workel,
- Dominik Loiero,
- David N. Church,
- Lisa Vermij,
- Alicia Léon-Castillo,
- Ricki T. Krog,
- Stephanie M. de Boer,
- Remi A. Nout,
- Melanie E. Powell,
- Linda R. Mileshkin,
- Helen MacKay,
- Alexandra Leary,
- Naveena Singh,
- Ina M. Jürgenliemk-Schulz,
- Vincent T. H. B. M. Smit,
- Carien L. Creutzberg,
- Viktor H. Koelzer,
- Hans W. Nijman,
- Tjalling Bosse,
- Marco de Bruyn,
- TransPORTEC consortium
Affiliations
- Nanda Horeweg
- Department of Radiation Oncology, Leiden University Medical Center
- Hagma H. Workel
- Department of Gynaecologic Oncology, University Medical Center Groningen
- Dominik Loiero
- Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich
- David N. Church
- Wellcome Centre for Human Genetics, University of Oxford
- Lisa Vermij
- Department of Pathology, Leiden University Medical Center
- Alicia Léon-Castillo
- Department of Pathology, Leiden University Medical Center
- Ricki T. Krog
- Department of Pathology, Leiden University Medical Center
- Stephanie M. de Boer
- Department of Radiation Oncology, Leiden University Medical Center
- Remi A. Nout
- Department of Radiotherapy, Erasmus MC Cancer Institute
- Melanie E. Powell
- Department of Clinical Oncology, Barts Health NHS Trust
- Linda R. Mileshkin
- Department of Medical Oncology, Peter MacCallum Cancer Centre
- Helen MacKay
- Division of Medical Oncology and Hematology, Sunnybrook Odette Cancer Centre
- Alexandra Leary
- Department of Medical Oncology, Gustave Roussy
- Naveena Singh
- Department of Pathology, Barts Health NHS Trust
- Ina M. Jürgenliemk-Schulz
- Department of Radiation Oncology, University Medical Center Utrecht
- Vincent T. H. B. M. Smit
- Department of Pathology, Leiden University Medical Center
- Carien L. Creutzberg
- Department of Radiation Oncology, Leiden University Medical Center
- Viktor H. Koelzer
- Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich
- Hans W. Nijman
- Department of Gynaecologic Oncology, University Medical Center Groningen
- Tjalling Bosse
- Department of Pathology, Leiden University Medical Center
- Marco de Bruyn
- Department of Gynaecologic Oncology, University Medical Center Groningen
- TransPORTEC consortium
- DOI
- https://doi.org/10.1038/s41467-022-29040-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Tertiary lymphoid structures (TLS) are associated with a reduced risk of cancer recurrence and improved response to immune checkpoint blockade in several tumor types. Here the authors identify L1CAM as a marker for mature TLS and show that the presence of TLS is associated with favorable prognosis in patients with endometrial cancer from the PORTEC-3 trial.
