Recurrent Miscarriage and Associated Factors

Abstract

The incidence of recurrent pregnancy loss in women of reproductive age group is 0.5%–3%, And idiopathic causes accounts for 50%–60% of recurrent pregnancy losses. Approximately 30%–50% of conceptions end in spontaneous miscarriage before the completion of first trimester. Miscarriages mostly occur at the time of implantation. The causes of recurrent pregnancy loss are many including parental chromosomal abnormalities, maternal thrombophilias, immunologic causes and endocrine disorders. Recurrent pregnancy loss is an extremely distressing clinical problem for women as well as health professinals. According to current studies the decidualized endometrium act as a biosensor of good quality embyos , if it is faulty ,may lead to implantation of embryos resulting in miscarriage. Other factors implicated in the pathophysiology of miscarriage are Systemic and placental oxidative stress. Vascular endothelial damage, abnormal vascularity of placenta and immunologic reactions have been proposed to play some role in causing recurrent miscarriage. The objective of this review is to discuss the causes of recurrent miscarriage, based on the published research articles. Key Words: Recurrent pregnancy loss, Immunology, Miscarriage.