Evaluating the association between DNM1L variants and Parkinson's disease in the Chinese population

Jiabin Liu; Juanjuan Huang; Yuwen Zhao; Hongxu Pan; Yige Wang; Zhenhua Liu; Qian Xu; Qiying Sun; Jieqiong Tan; Xinxiang Yan; Jinchen Li; Jinchen Li; Beisha Tang; Beisha Tang; Beisha Tang; Beisha Tang; Beisha Tang; Jifeng Guo; Jifeng Guo; Jifeng Guo; Jifeng Guo; Jifeng Guo; Jifeng Guo

doi:10.3389/fneur.2023.1133449

Frontiers in Neurology (Feb 2023)

Evaluating the association between DNM1L variants and Parkinson's disease in the Chinese population

Jiabin Liu,
Juanjuan Huang,
Yuwen Zhao,
Hongxu Pan,
Yige Wang,
Zhenhua Liu,
Qian Xu,
Qiying Sun,
Jieqiong Tan,
Xinxiang Yan,
Jinchen Li,
Jinchen Li,
Beisha Tang,
Beisha Tang,
Beisha Tang,
Beisha Tang,
Beisha Tang,
Jifeng Guo,
Jifeng Guo,
Jifeng Guo,
Jifeng Guo,
Jifeng Guo,
Jifeng Guo

Affiliations

Jiabin Liu: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Juanjuan Huang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Yuwen Zhao: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Hongxu Pan: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Yige Wang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Zhenhua Liu: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Qian Xu: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Qiying Sun: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Jieqiong Tan: Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China
Xinxiang Yan: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Jinchen Li: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Jinchen Li: Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China
Beisha Tang: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Beisha Tang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Beisha Tang: Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China
Beisha Tang: Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China
Beisha Tang: Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China
Jifeng Guo: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Jifeng Guo: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China
Jifeng Guo: Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China
Jifeng Guo: Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China
Jifeng Guo: Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China
Jifeng Guo: Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fneur.2023.1133449
Journal volume & issue: Vol. 14

Abstract

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IntroductionParkinson's disease (PD) is a progressive movement disorder caused by a loss of dopaminergic neurons. Previous studies have highlighted the importance of mitochondria dynamics in the pathogenesis of PD. Dynamin-1-like (DNM1L) is a gene that encodes dynamin-related protein 1 (DRP1), a GTPase essential for proper mitochondria fission. In the present study, we evaluated the relationship between DNM1L variants and PD in the Chinese population.MethodsA total of 3,879 patients with PD and 2,931 healthy controls were recruited and burden genetic analysis combined with high-throughput sequencing was applied.ResultsWe identified 23 rare variants in the coding region of DNM1L, while no difference in variant burden was shown between the cases and controls. We also identified 201 common variants in the coding and flanking regions and found two significant SNPs, namely, rs10844308 and rs143794289 [odds ratio (OR) = 1.220 and 0.718, p = 0.025 and 0.036, respectively]. We also performed a meta-analysis to correlate the two SNPs with PD risk. However, none of the common variants was significant using logistic regression.ConclusionDespite the critical role of DRP1, our study did not support the relationship between DNM1L variants and PD risk in the Chinese population.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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