Nature Communications (Jun 2020)
An Erg-driven transcriptional program controls B cell lymphopoiesis
- Ashley P. Ng,
- Hannah D. Coughlan,
- Soroor Hediyeh-zadeh,
- Kira Behrens,
- Timothy M. Johanson,
- Michael Sze Yuan Low,
- Charles C. Bell,
- Omer Gilan,
- Yih-Chih Chan,
- Andrew J. Kueh,
- Thomas Boudier,
- Rebecca Feltham,
- Anna Gabrielyan,
- Ladina DiRago,
- Craig D. Hyland,
- Helen Ierino,
- Sandra Mifsud,
- Elizabeth Viney,
- Tracy Willson,
- Mark A. Dawson,
- Rhys S. Allan,
- Marco J. Herold,
- Kelly Rogers,
- David M. Tarlinton,
- Gordon K. Smyth,
- Melissa J. Davis,
- Stephen L. Nutt,
- Warren S. Alexander
Affiliations
- Ashley P. Ng
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Hannah D. Coughlan
- Department of Medical Biology, The University of Melbourne
- Soroor Hediyeh-zadeh
- Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research
- Kira Behrens
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Timothy M. Johanson
- Department of Medical Biology, The University of Melbourne
- Michael Sze Yuan Low
- Department of Medical Biology, The University of Melbourne
- Charles C. Bell
- Peter MacCallum Cancer Centre
- Omer Gilan
- Peter MacCallum Cancer Centre
- Yih-Chih Chan
- Peter MacCallum Cancer Centre
- Andrew J. Kueh
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Thomas Boudier
- Department of Medical Biology, The University of Melbourne
- Rebecca Feltham
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- Anna Gabrielyan
- Inflammation Division, The Walter and Eliza Hall Institute of Medical Research
- Ladina DiRago
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Craig D. Hyland
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Helen Ierino
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Sandra Mifsud
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Elizabeth Viney
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Tracy Willson
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Mark A. Dawson
- Peter MacCallum Cancer Centre
- Rhys S. Allan
- Department of Medical Biology, The University of Melbourne
- Marco J. Herold
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- Kelly Rogers
- Department of Medical Biology, The University of Melbourne
- David M. Tarlinton
- Department of Immunology and Pathology, Monash University
- Gordon K. Smyth
- Department of Medical Biology, The University of Melbourne
- Melissa J. Davis
- Department of Medical Biology, The University of Melbourne
- Stephen L. Nutt
- Department of Medical Biology, The University of Melbourne
- Warren S. Alexander
- Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-020-16828-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically control two downstream factors, Ebf1 and Pax5, for modulating this gene rearrangement process.
