Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

José Carlos Santos; Dave Boucher; Larisa Kapinos Schneider; Benjamin Demarco; Marisa Dilucca; Kateryna Shkarina; Rosalie Heilig; Kaiwen W. Chen; Roderick Y. H. Lim; Petr Broz

doi:10.1038/s41467-020-16889-z

Nature Communications (Jun 2020)

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

José Carlos Santos,
Dave Boucher,
Larisa Kapinos Schneider,
Benjamin Demarco,
Marisa Dilucca,
Kateryna Shkarina,
Rosalie Heilig,
Kaiwen W. Chen,
Roderick Y. H. Lim,
Petr Broz

Affiliations

José Carlos Santos: Department of Biochemistry, University of Lausanne
Dave Boucher: Department of Biochemistry, University of Lausanne
Larisa Kapinos Schneider: Biozentrum, University of Basel
Benjamin Demarco: Department of Biochemistry, University of Lausanne
Marisa Dilucca: Department of Biochemistry, University of Lausanne
Kateryna Shkarina: Department of Biochemistry, University of Lausanne
Rosalie Heilig: Department of Biochemistry, University of Lausanne
Kaiwen W. Chen: Department of Biochemistry, University of Lausanne
Roderick Y. H. Lim: Biozentrum, University of Basel
Petr Broz: Department of Biochemistry, University of Lausanne

DOI: https://doi.org/10.1038/s41467-020-16889-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Detection of LPS derived from Gram-negative bacteria by innate immune receptors is a critical step in the host response. Here Santos and colleagues show human GBP1 binds to LPS resulting in non-canonical inflammasome activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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