The role of mitochondrial dysfunction in Alzheimer’s disease

Abstract

This review presents and discusses evidence demonstrating the importance of mitochondria and related processes in the pathogenesis of Alzheimer's disease. Mitochondrial dysfunction is currently emerging as a potential therapeutic target in the treatment of Alzheimer's disease and other neurodegenerative diseases. This paper also reviews various drug strategies aimed at mitochondrial dysfunction and the development of oxidative stress.

Keywords

• alzheimer’s disease
• mitochondria
• mitochondrial dysfunction
• oxidative stress
• coenzyme 010
• idebenon