Magnetic biomaterials with nanostructures for improved medication delivery and bone regeneration. First-level investigation

Abstract

ABSTRACTThe co-precipitation method is used in the lab to create a sample of the ferromagnetic 45CaO-30P2O5-15SiO2-10Fe2O3 (mol%). In simulated body fluid (SBF), the ability of the ferromagnetic sample to regenerate bone was examined, and XRD and FTIR graphs demonstrate that bone formation has taken place. The Vibration Sample Magnetometer has confirmed that the sample’s ferromagnetic behavior was brought on by the presence of iron (VSM). When an external magnetic field is present, the resulting sample may be utilized to treat bone cancer due to its ferromagnetic nature (hyperthermia). The sample’s drug release is therefore tested both with and without the help of an external magnetic field, and the findings reveal that when the magnetic field is present, the sample displays good drug release. BET analysis also supports the capacity of drugs to load and release. The sample’s ability to distribute drugs is tested using the antibiotic gentamicin. The prolonged release of the medication in SBF solution is investigated using a first-order kinetic equation. Being a drug-loaded ferromagnetic sample with high magnetic attraction, makes it simple to target any nearby spot. With a cytotoxicity rate of more than 90%, the produced sample is seen to interact amicably with the MG-63 human cell line. According to antimicrobial research, samples also guard against both gram-positive and gram-negative germs in the implant region. By lowering the cell’s oxidative stress, the sample’s antioxidant activity aids in cell proliferation, which increases the implanted site’s recuperation.

Keywords

• Bioactive ceramics
• drug delivery
• bone regenration
• SBF
• bioactive