Nature Communications (Apr 2019)

A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme

  • Ankita J. Sachla,
  • John D. Helmann

DOI
https://doi.org/10.1038/s41467-019-09508-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Adventitious oxidation of erythrose-4-phosphate generates 4-phosphoerythronate, which is detoxified by metabolite-proofreading phosphatases in eukaryotes. Here, Sachla & Helmann show that a similar function is carried out in Bacillus subtilis by a checkpoint protein involved in ribosome assembly.