Decatungstate-catalyzed radical disulfuration through direct C-H functionalization for the preparation of unsymmetrical disulfides

Abstract

Despite the importance of unsymmetrical disulfides in various fields such as food chemistry, pharmaceutical industry, and polymer science, the nondirected intermolecular disulfuration of C-H bonds remains challenging. Here, the authors report the conversion of aliphatic C(sp3)-H bonds and aldehydic C(sp2)-H bonds into the corresponding C-SS bonds with tetrasulfides (RSSSSR) as radical disulfuration reagents.