Nature Communications (May 2016)
The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes
- Bernard Pereira,
- Suet-Feung Chin,
- Oscar M. Rueda,
- Hans-Kristian Moen Vollan,
- Elena Provenzano,
- Helen A. Bardwell,
- Michelle Pugh,
- Linda Jones,
- Roslin Russell,
- Stephen-John Sammut,
- Dana W. Y. Tsui,
- Bin Liu,
- Sarah-Jane Dawson,
- Jean Abraham,
- Helen Northen,
- John F. Peden,
- Abhik Mukherjee,
- Gulisa Turashvili,
- Andrew R. Green,
- Steve McKinney,
- Arusha Oloumi,
- Sohrab Shah,
- Nitzan Rosenfeld,
- Leigh Murphy,
- David R. Bentley,
- Ian O. Ellis,
- Arnie Purushotham,
- Sarah E. Pinder,
- Anne-Lise Børresen-Dale,
- Helena M. Earl,
- Paul D. Pharoah,
- Mark T. Ross,
- Samuel Aparicio,
- Carlos Caldas
Affiliations
- Bernard Pereira
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- Suet-Feung Chin
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- Oscar M. Rueda
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- Hans-Kristian Moen Vollan
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, Oslo 0310, Norway
- Elena Provenzano
- Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre
- Helen A. Bardwell
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- Michelle Pugh
- Inivata, Li Ka Shing Centre, Robinson Way
- Linda Jones
- Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre
- Roslin Russell
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- Stephen-John Sammut
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- Dana W. Y. Tsui
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- Bin Liu
- Department of Oncology, University of Cambridge
- Sarah-Jane Dawson
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- Jean Abraham
- Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre
- Helen Northen
- Illumina, Chesterford Research Park, Little Chesterford
- John F. Peden
- Illumina, Chesterford Research Park, Little Chesterford
- Abhik Mukherjee
- Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS Trust
- Gulisa Turashvili
- Department of Pathology and Molecular Medicine, Queen’s University/Kingston General Hospital
- Andrew R. Green
- Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS Trust
- Steve McKinney
- Department of Molecular Oncology, British Columbia Cancer Research Centre
- Arusha Oloumi
- Department of Molecular Oncology, British Columbia Cancer Research Centre
- Sohrab Shah
- Department of Molecular Oncology, British Columbia Cancer Research Centre
- Nitzan Rosenfeld
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- Leigh Murphy
- Research Institute in Oncology and Hematology
- David R. Bentley
- Illumina, Chesterford Research Park, Little Chesterford
- Ian O. Ellis
- Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS Trust
- Arnie Purushotham
- Cancer Division, NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and Research Oncology, King’s College London
- Sarah E. Pinder
- Cancer Division, NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and Research Oncology, King’s College London
- Anne-Lise Børresen-Dale
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, Oslo 0310, Norway
- Helena M. Earl
- Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre
- Paul D. Pharoah
- Strangeways Research Laboratory, University of Cambridge
- Mark T. Ross
- Illumina, Chesterford Research Park, Little Chesterford
- Samuel Aparicio
- Department of Molecular Oncology, British Columbia Cancer Research Centre
- Carlos Caldas
- Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Robinson Way
- DOI
- https://doi.org/10.1038/ncomms11479
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Much effort has recently been devoted to understanding the genomics of breast cancer. In this study, the authors integrate somatic mutation data with previously published copy number aberration and gene expression information for nearly 2,500 breast cancer samples.
