miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

Zhenhua Xu; Yiwen Bu; Nilesh Chitnis; Costas Koumenis; Serge Y. Fuchs; J. Alan Diehl

doi:10.1038/ncomms11422

Nature Communications (May 2016)

miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis

Zhenhua Xu,
Yiwen Bu,
Nilesh Chitnis,
Costas Koumenis,
Serge Y. Fuchs,
J. Alan Diehl

Affiliations

Zhenhua Xu: Department of Biochemistry, Hollings Cancer Center, Medical University of South Carolina
Yiwen Bu: Department of Biochemistry, Hollings Cancer Center, Medical University of South Carolina
Nilesh Chitnis: Department of Biochemistry, Hollings Cancer Center, Medical University of South Carolina
Costas Koumenis: Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania
Serge Y. Fuchs: Department of Animal Biology, School of Veterinary Medicine, 380 S. University Avenue
J. Alan Diehl: Department of Biochemistry, Hollings Cancer Center, Medical University of South Carolina

DOI: https://doi.org/10.1038/ncomms11422
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The transcription factor CHOP/GADD153 regulates apoptosis in response to the unfolded protein response. Here the authors show that CHOP/GADD153 regulates the expression of miR-216b, which targets c-Jun and sensitizes cells to ER stress-dependent apoptosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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