Nature Communications (Dec 2022)

LY6D marks pre-existing resistant basosquamous tumor subpopulations

  • Daniel Haensel,
  • Sadhana Gaddam,
  • Nancy Y. Li,
  • Fernanda Gonzalez,
  • Tiffany Patel,
  • Jeffrey M. Cloutier,
  • Kavita Y. Sarin,
  • Jean Y. Tang,
  • Kerri E. Rieger,
  • Sumaira Z. Aasi,
  • Anthony E. Oro

DOI
https://doi.org/10.1038/s41467-022-35020-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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The identification of distinct cell populations with cellular plasticity in skin basal cell carcinoma is important for understanding treatment resistance mechanisms. Here, the authors identify the resistant LY6D+ basosquamous population that correlates with poor clinical outcomes.