Zhongguo quanke yixue (Jul 2024)

Research Progress of Astrocyte-derived Extracellular Vesicles in Post-stroke Cognitive Impairment

  • XIAO Yuqian, BAI Yanjie, WANG Yan, SUN Kexin, WAN Jun, CHEN Shuying, CHEN Limin

DOI
https://doi.org/10.12114/j.issn.1007-9572.2023.0412
Journal volume & issue
Vol. 27, no. 20
pp. 2551 – 2556

Abstract

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Post-stroke cognitive impairment, characterized by cognitive dysfunction, is a common complication of stroke and has a direct impact on the quality of life of ischemic stroke patients. Previous studies have found that astrocytes play an important role in the pathogenesis of PSCI. In addition, extracellular vesicles (EVs) have been recognized as an important medium for intercellular communication and are involved in various pathophysiological processes by carrying and transporting various cargoes. Astrocyte-derived extracellular vesicles (ADEVs) may communicate with other brain cells to improve PSCI by enhancing synaptic plasticity, modulating neuroinflammation, regulating angiogenesis and autophagy. This review clarifies the multiple effects of ADEVs on the development of PSCI, offers new strategies for studying the underlying mechanisms of PSCI, and further explores the potential uses of ADEVs as novel drugs and biomarkers in the diagnosis and treatment of PSCI.

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