False-seronegative HCV infection motivated by interference with cryoglobulins

Recio Comí Gemma; Molina Clavero Carmen; Calabuig Ballester Sandra; Benavent Bofill Clara; Picó-Plana Ester; Martín Grau Carla; Gutiérrez Fornés Cristina; Sans Mateu Ma Teresa

doi:10.1515/almed-2020-0086

Advances in Laboratory Medicine (Apr 2021)

False-seronegative HCV infection motivated by interference with cryoglobulins

Recio Comí Gemma,
Molina Clavero Carmen,
Calabuig Ballester Sandra,
Benavent Bofill Clara,
Picó-Plana Ester,
Martín Grau Carla,
Gutiérrez Fornés Cristina,
Sans Mateu Ma Teresa

Affiliations

Recio Comí Gemma: Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l’Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain
Molina Clavero Carmen: Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l’Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain
Calabuig Ballester Sandra: Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l’Ebre – Verge de la Cinta Hospital in Tortosa, Tarragona, Spain
Benavent Bofill Clara: Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l’Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain
Picó-Plana Ester: Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l’Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain
Martín Grau Carla: Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l’Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain
Gutiérrez Fornés Cristina: Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l’Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain
Sans Mateu Ma Teresa: Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l’Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain

DOI: https://doi.org/10.1515/almed-2020-0086
Journal volume & issue: Vol. 2, no. 2
pp. 297 – 300

Abstract

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Cryoglobulins (CGs) are serum proteins that undergo a reverse cold-induced precipitation in vitro. The CGs are a well-known cause of analytical interferences in several laboratory tests, leading to spurious results. With this in view, we present a case of a patient initially misdiagnosed due to CGs interference in Hepatitis C Virus (HCV) serology.

Published in Advances in Laboratory Medicine

ISSN: 2628-491X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Medicine: Medicine (General): Medical technology
Website: https://www.degruyter.com/journal/key/almed/html

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