3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering

Annan Chen; Jin Su; Yinjin Li; Haibo Zhang; Yusheng Shi; Chunze Yan; Jian Lu

doi:10.1088/2631-7990/acd88f

International Journal of Extreme Manufacturing (Jan 2023)

3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering

Annan Chen,
Jin Su,
Yinjin Li,
Haibo Zhang,
Yusheng Shi,
Chunze Yan,
Jian Lu

Affiliations

Annan Chen: State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology , Wuhan 430074, People’s Republic of China; Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of Education , Wuhan 430074, People’s Republic of China; Centre for Advanced Structural Materials, Department of Mechanical Engineering, City University of Hong Kong , Hong Kong, People’s Republic of China
Jin Su: State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology , Wuhan 430074, People’s Republic of China; Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of Education , Wuhan 430074, People’s Republic of China
Yinjin Li: State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology , Wuhan 430074, People’s Republic of China; Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of Education , Wuhan 430074, People’s Republic of China
Haibo Zhang: State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology , Wuhan 430074, People’s Republic of China
Yusheng Shi: State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology , Wuhan 430074, People’s Republic of China; Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of Education , Wuhan 430074, People’s Republic of China
Chunze Yan: State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology , Wuhan 430074, People’s Republic of China; Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of Education , Wuhan 430074, People’s Republic of China
Jian Lu: ORCiD; Centre for Advanced Structural Materials, Department of Mechanical Engineering, City University of Hong Kong , Hong Kong, People’s Republic of China; Centre for Advanced Structural Materials, City University of Hong Kong Shenzhen Research Institute, Greater Bay Joint Division, Shenyang National Laboratory for Materials Science , Shenzhen 518057, People’s Republic of China; CityU-Shenzhen Futian Research Institute , Shenzhen 518045, People’s Republic of China

DOI: https://doi.org/10.1088/2631-7990/acd88f
Journal volume & issue: Vol. 5, no. 3
p. 032007

Abstract

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Piezoelectricity in native bones has been well recognized as the key factor in bone regeneration. Thus, bio-piezoelectric materials have gained substantial attention in repairing damaged bone by mimicking the tissue’s electrical microenvironment (EM). However, traditional manufacturing strategies still encounter limitations in creating personalized bio-piezoelectric scaffolds, hindering their clinical applications. Three-dimensional (3D)/four-dimensional (4D) printing technology based on the principle of layer-by-layer forming and stacking of discrete materials has demonstrated outstanding advantages in fabricating bio-piezoelectric scaffolds in a more complex-shaped structure. Notably, 4D printing functionality-shifting bio-piezoelectric scaffolds can provide a time-dependent programmable tissue EM in response to external stimuli for bone regeneration. In this review, we first summarize the physicochemical properties of commonly used bio-piezoelectric materials (including polymers, ceramics, and their composites) and representative biological findings for bone regeneration. Then, we discuss the latest research advances in the 3D printing of bio-piezoelectric scaffolds in terms of feedstock selection, printing process, induction strategies, and potential applications. Besides, some related challenges such as feedstock scalability, printing resolution, stress-to-polarization conversion efficiency, and non-invasive induction ability after implantation have been put forward. Finally, we highlight the potential of shape/property/functionality-shifting smart 4D bio-piezoelectric scaffolds in bone tissue engineering (BTE). Taken together, this review emphasizes the appealing utility of 3D/4D printed biological piezoelectric scaffolds as next-generation BTE implants.

Published in International Journal of Extreme Manufacturing

ISSN: 2631-8644 (Print); 2631-7990 (Online)
Publisher: IOP Publishing
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Technology: Technology (General): Industrial engineering. Management engineering; Science: Physics
Website: https://iopscience.iop.org/journal/2631-7990

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