Pharmaceuticals (Mar 2021)
The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives
- François Pognan,
- Thomas Steger-Hartmann,
- Carlos Díaz,
- Niklas Blomberg,
- Frank Bringezu,
- Katharine Briggs,
- Giulia Callegaro,
- Salvador Capella-Gutierrez,
- Emilio Centeno,
- Javier Corvi,
- Philip Drew,
- William C. Drewe,
- José M. Fernández,
- Laura I. Furlong,
- Emre Guney,
- Jan A. Kors,
- Miguel Angel Mayer,
- Manuel Pastor,
- Janet Piñero,
- Juan Manuel Ramírez-Anguita,
- Francesco Ronzano,
- Philip Rowell,
- Josep Saüch-Pitarch,
- Alfonso Valencia,
- Bob van de Water,
- Johan van der Lei,
- Erik van Mulligen,
- Ferran Sanz
Affiliations
- François Pognan
- Preclinical Safety/Translational Medicine, Novartis, 4057 Basel, Switzerland
- Thomas Steger-Hartmann
- Pharmaceuticals, Investigational Toxicology, Bayer AG, 13342 Berlin, Germany
- Carlos Díaz
- Synapse Research Managers SL, 28006 Madrid, Spain
- Niklas Blomberg
- ELIXIR, Hinxton, Cambridgeshire CB10 1SD, UK
- Frank Bringezu
- Chemical & Preclinical Safety, Merck Healthcare KGaA, 64293 Darmstadt, Germany
- Katharine Briggs
- Lhasa Limited, Leeds LS11 5PS, UK
- Giulia Callegaro
- Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2300 RA Leiden, The Netherlands
- Salvador Capella-Gutierrez
- Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain
- Emilio Centeno
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- Javier Corvi
- Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain
- Philip Drew
- PDS Consultants, Leicester LE1 5XY, UK
- William C. Drewe
- Lhasa Limited, Leeds LS11 5PS, UK
- José M. Fernández
- Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain
- Laura I. Furlong
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- Emre Guney
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- Jan A. Kors
- Department of Medical Informatics, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands
- Miguel Angel Mayer
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- Manuel Pastor
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- Janet Piñero
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- Juan Manuel Ramírez-Anguita
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- Francesco Ronzano
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- Philip Rowell
- Lhasa Limited, Leeds LS11 5PS, UK
- Josep Saüch-Pitarch
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- Alfonso Valencia
- Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain
- Bob van de Water
- Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2300 RA Leiden, The Netherlands
- Johan van der Lei
- Department of Medical Informatics, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands
- Erik van Mulligen
- Department of Medical Informatics, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands
- Ferran Sanz
- GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
- DOI
- https://doi.org/10.3390/ph14030237
- Journal volume & issue
-
Vol. 14,
no. 3
p. 237
Abstract
eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.
Keywords
- toxicology
- drug safety
- translational safety assessment
- data sharing
- integrative knowledge management
- data mining
