Research progress on the role and mechanism of ADAMTS9 in atherosclerosis

Abstract

Atherosclerosis is an inflammatory disease of arterial stenosis caused by the imbalance of lipid metabolism and atherosclerotic plaques clustered on the arterial wall. It is the main pathological process of vascular diseases， such as stroke and coronary heart disease， etc. Atherosclerotic diseases yield high disability and death rates. Recent relevant studies have reported that ADAMTS9 is closely correlated with vascular pathophysiological processes. ADAMTS9 can degrade and assemble extracellular matrix， enhance vascular smooth muscle cell proliferation and migration， provoke pro-inflammatory response， promote intimal thickening， accelerate plaque rupture， and exert anti-angiogenesis effect. In this article， the role and mechanism of ADAMTS9 in the incidence and development of atherosclerosis were mainly summarized.

Keywords

• atherosclerosis|adamts9|gene polymorphism