Nature Communications (Mar 2023)
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
- Andre Mu,
- William P. Klare,
- Sarah L. Baines,
- C. N. Ignatius Pang,
- Romain Guérillot,
- Nichaela Harbison-Price,
- Nadia Keller,
- Jonathan Wilksch,
- Nguyen Thi Khanh Nhu,
- Minh-Duy Phan,
- Bernhard Keller,
- Brunda Nijagal,
- Dedreia Tull,
- Saravanan Dayalan,
- Hwa Huat Charlie Chua,
- Dominik Skoneczny,
- Jason Koval,
- Abderrahman Hachani,
- Anup D. Shah,
- Nitika Neha,
- Snehal Jadhav,
- Sally R. Partridge,
- Amanda J. Cork,
- Kate Peters,
- Olivia Bertolla,
- Stephan Brouwer,
- Steven J. Hancock,
- Laura Álvarez-Fraga,
- David M. P. De Oliveira,
- Brian Forde,
- Ashleigh Dale,
- Warasinee Mujchariyakul,
- Calum J. Walsh,
- Ian Monk,
- Anna Fitzgerald,
- Mabel Lum,
- Carolina Correa-Ospina,
- Piklu Roy Chowdhury,
- Robert G. Parton,
- James De Voss,
- James Beckett,
- Francois Monty,
- Jessica McKinnon,
- Xiaomin Song,
- John R. Stephen,
- Marie Everest,
- Matt I. Bellgard,
- Matthew Tinning,
- Michael Leeming,
- Dianna Hocking,
- Leila Jebeli,
- Nancy Wang,
- Nouri Ben Zakour,
- Serhat A. Yasar,
- Stefano Vecchiarelli,
- Tonia Russell,
- Thiri Zaw,
- Tyrone Chen,
- Don Teng,
- Zena Kassir,
- Trevor Lithgow,
- Adam Jenney,
- Jason N. Cole,
- Victor Nizet,
- Tania C. Sorrell,
- Anton Y. Peleg,
- David L. Paterson,
- Scott A. Beatson,
- Jemma Wu,
- Mark P. Molloy,
- Anna E. Syme,
- Robert J. A. Goode,
- Adam A. Hunter,
- Grahame Bowland,
- Nicholas P. West,
- Marc R. Wilkins,
- Steven P. Djordjevic,
- Mark R. Davies,
- Torsten Seemann,
- Benjamin P. Howden,
- Dana Pascovici,
- Sonika Tyagi,
- Ralf B. Schittenhelm,
- David P. De Souza,
- Malcolm J. McConville,
- Jonathan R. Iredell,
- Stuart J. Cordwell,
- Richard A. Strugnell,
- Timothy P. Stinear,
- Mark A. Schembri,
- Mark J. Walker
Affiliations
- Andre Mu
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- William P. Klare
- Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney
- Sarah L. Baines
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- C. N. Ignatius Pang
- Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Romain Guérillot
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Nichaela Harbison-Price
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Nadia Keller
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Jonathan Wilksch
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Nguyen Thi Khanh Nhu
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Minh-Duy Phan
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Bernhard Keller
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Brunda Nijagal
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Dedreia Tull
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Saravanan Dayalan
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Hwa Huat Charlie Chua
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Dominik Skoneczny
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Jason Koval
- Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Abderrahman Hachani
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Anup D. Shah
- Monash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University
- Nitika Neha
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Snehal Jadhav
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Sally R. Partridge
- Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney
- Amanda J. Cork
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Kate Peters
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Olivia Bertolla
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Stephan Brouwer
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Steven J. Hancock
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Laura Álvarez-Fraga
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- David M. P. De Oliveira
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Brian Forde
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Ashleigh Dale
- Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney
- Warasinee Mujchariyakul
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Calum J. Walsh
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Ian Monk
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Anna Fitzgerald
- Bioplatforms Australia Ltd.
- Mabel Lum
- Bioplatforms Australia Ltd.
- Carolina Correa-Ospina
- Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Piklu Roy Chowdhury
- Australian Institute for Microbiology and Infection, University of Technology Sydney
- Robert G. Parton
- Institute for Molecular Bioscience, The University of Queensland
- James De Voss
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- James Beckett
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Francois Monty
- Australian Genome Research Facility Ltd.
- Jessica McKinnon
- Australian Institute for Microbiology and Infection, University of Technology Sydney
- Xiaomin Song
- Australian Proteome Analysis Facility, Macquarie University
- John R. Stephen
- Australian Genome Research Facility Ltd.
- Marie Everest
- Australian Genome Research Facility Ltd.
- Matt I. Bellgard
- Office of eResearch, Queensland University of Technology
- Matthew Tinning
- Australian Genome Research Facility Ltd.
- Michael Leeming
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Dianna Hocking
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Leila Jebeli
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Nancy Wang
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Nouri Ben Zakour
- Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney
- Serhat A. Yasar
- Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Stefano Vecchiarelli
- Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Tonia Russell
- Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Thiri Zaw
- Australian Proteome Analysis Facility, Macquarie University
- Tyrone Chen
- Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University
- Don Teng
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Zena Kassir
- Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Trevor Lithgow
- Centre to Impact AMR and Infection Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
- Adam Jenney
- Centre to Impact AMR and Infection Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
- Jason N. Cole
- Department of Pediatrics, School of Medicine, University of California at San Diego
- Victor Nizet
- Department of Pediatrics, School of Medicine, University of California at San Diego
- Tania C. Sorrell
- Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney
- Anton Y. Peleg
- Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University
- David L. Paterson
- Centre for Clinical Research, The University of Queensland
- Scott A. Beatson
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Jemma Wu
- Australian Proteome Analysis Facility, Macquarie University
- Mark P. Molloy
- Australian Proteome Analysis Facility, Macquarie University
- Anna E. Syme
- Melbourne Bioinformatics, The University of Melbourne
- Robert J. A. Goode
- Monash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University
- Adam A. Hunter
- Center for Comparative Genomics, Murdoch University
- Grahame Bowland
- Center for Comparative Genomics, Murdoch University
- Nicholas P. West
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Marc R. Wilkins
- Ramaciotti Centre for Genomics, School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Steven P. Djordjevic
- Australian Institute for Microbiology and Infection, University of Technology Sydney
- Mark R. Davies
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Torsten Seemann
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Benjamin P. Howden
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Dana Pascovici
- Australian Proteome Analysis Facility, Macquarie University
- Sonika Tyagi
- Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University
- Ralf B. Schittenhelm
- Monash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University
- David P. De Souza
- Metabolomics Australia, Bio21 Institute, The University of Melbourne
- Malcolm J. McConville
- Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
- Jonathan R. Iredell
- Centre for Infectious Diseases and Microbiology, Westmead Hospital/ Westmead Institute, and Sydney ID, University of Sydney
- Stuart J. Cordwell
- Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney
- Richard A. Strugnell
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Timothy P. Stinear
- Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Mark A. Schembri
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- Mark J. Walker
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland
- DOI
- https://doi.org/10.1038/s41467-023-37200-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well as cholesterol acquisition.
