Frequency of and factors associated with vascular complications after pediatric liver transplantation

Abstract

Objective: to evaluate the frequency and factors associated with vascular complications after pediatric liver transplantation. Method: risk factors were evaluated in 99 patients under 18 years of age with chronic liver disease who underwent deceased donor liver transplantation (DDLT) between March of 1995 and November of 2009 at the Hospital de Clínicas de Porto Alegre, Brazil. The variables analyzed included donor and recipient age, gender, and weight; indication for transplant; PELD/MELD scores; technical aspects; postoperative vascular complications; and survival. Results: vascular complications occurred in 19 patients (19%). Arterial events were most common, occurred earlier in the postoperative period, and were associated with high graft loss andmortality rates. In the multivariate analysis, the following factors were identified: portal veindiameter ≤ 3 mm, donor-to-recipient body weight ratio (DRWR), prolonged ischemic time, and use of arterial grafts. Conclusion: the choice of treatment depends on the timing of diagnosis; however, in this study, surgical revision or correction produced worse outcomes than percutaneous angioplasty. The reduction of risk factors and early detection of vascular complications are key elements to a successful transplantation.

Keywords

• Thrombosis
• Hepatic artery
• Portal vein
• Morbidity
• Mortality