Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation

Violet R. Mukaro; Alex Quach; Michelle E. Gahan; Bernadette Boog; Zhi H. Huang; Xiuhui Gao; Carol Haddad; Suresh Mahalingam; Charles S. Hii; Antonio Ferrante

doi:10.1038/s41467-018-03640-y

Nature Communications (Apr 2018)

Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation

Violet R. Mukaro,
Alex Quach,
Michelle E. Gahan,
Bernadette Boog,
Zhi H. Huang,
Xiuhui Gao,
Carol Haddad,
Suresh Mahalingam,
Charles S. Hii,
Antonio Ferrante

Affiliations

Violet R. Mukaro: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital
Alex Quach: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital
Michelle E. Gahan: Faculty of Science and Technology, University of Canberra
Bernadette Boog: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital
Zhi H. Huang: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital
Xiuhui Gao: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital
Carol Haddad: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital
Suresh Mahalingam: Emerging Viruses and Inflammation Research Group, Institute of Glycomics, Griffith University
Charles S. Hii: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital
Antonio Ferrante: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital

DOI: https://doi.org/10.1038/s41467-018-03640-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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