Research Journal of Pharmacognosy (Oct 2019)

Pistachio Extract Improves Neurocognitive Behaviors in Ovariectomized Mice

  • Elham Hakimizadeh,
  • Faezeh Jandaghi,
  • Mojdeh Hajmohammadi,
  • Iman Fatemi,
  • Ayat Kaeidi,
  • Ali Sham‌sizadeh,
  • Mohammad Allahtavakoli*

DOI
https://doi.org/10.22127/rjp.2019.93515
Journal volume & issue
Vol. 6, no. 4
pp. 45 – 51

Abstract

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Background and objectives: Menopause is associated with depression as well as emotional and memory disorders. Based on the anti-inflammatory and antioxidant effects of pistachio, its effect on depression, cognitive function, anxiety and physical power in ovariectomized mice was investigated. Methods: In the current study, fifty female mice were used. They were aliquoted into five groups: control, ovariectomy (OVX), ovariectomy + DMSO, ovariectomy +10 mg/kg pistachioextract and Ovariectomy +100 mg/kg pistachio extract. In order to prepare the required extract, pistachio nuts were powdered (100 g) and macerated in 1 L of ethanol (80%) for 72 h. Pistachio extract was used orally once a day in ovariectomized mice for sixty days. Anxiety, depression, working memory and physical power were evaluated by the Elevated plus-maze (EPM) test, Forced swimming test (FST), Y maze and swimming exhaustion test, respectively. Results: The results showed that extract of pistachio (more potentially at the dose of 100 mg/kg) decreased anxiety-like behaviors and depression; besides, increase in working memory and physical power was observed in the ovariectomized mice. Conclusion: The findings of the current investigation suggest that pistachio extract could be used as a potential strategy for the attenuation of ovariectomy-related manifestation

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