Nature Communications (Mar 2023)
A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity
- Ellen Young,
- Boyd Yount,
- Petraleigh Pantoja,
- Sandra Henein,
- Rita M. Meganck,
- Jennifer McBride,
- Jennifer E. Munt,
- Thomas J. Baric,
- Deanna Zhu,
- Trevor Scobey,
- Stephanie Dong,
- Longping V. Tse,
- Melween I. Martinez,
- Armando G. Burgos,
- Rachel L. Graham,
- Laura White,
- Aravinda DeSilva,
- Carlos A. Sariol,
- Ralph S. Baric
Affiliations
- Ellen Young
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Boyd Yount
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Petraleigh Pantoja
- Unit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus
- Sandra Henein
- Department of Microbiology and Immunology, School of Medicine, University of North Carolina
- Rita M. Meganck
- Department of Molecular Microbiology and Immunology, Saint Louis University
- Jennifer McBride
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Jennifer E. Munt
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Thomas J. Baric
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Deanna Zhu
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Trevor Scobey
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Stephanie Dong
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Longping V. Tse
- Department of Molecular Microbiology and Immunology, Saint Louis University
- Melween I. Martinez
- Caribbean Primate Research Center, School of Medicine, University of Puerto Rico-Medical Sciences Campus
- Armando G. Burgos
- Caribbean Primate Research Center, School of Medicine, University of Puerto Rico-Medical Sciences Campus
- Rachel L. Graham
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Laura White
- Department of Microbiology and Immunology, School of Medicine, University of North Carolina
- Aravinda DeSilva
- Department of Microbiology and Immunology, School of Medicine, University of North Carolina
- Carlos A. Sariol
- Unit of Comparative Medicine, University of Puerto Rico-Medical Sciences Campus
- Ralph S. Baric
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- DOI
- https://doi.org/10.1038/s41467-023-36702-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
Here, the authors report a live chimeric DENV2/4 EDII virus, encoding DENV2 and DENV4 neutralizing epitopes, that replicates efficiently in primates and simultaneously elicits neutralizing DENV2 and DENV4 type-specific antibodies, providing domain-specific diagnostic reagents and simplified vaccine strategies.
