Novel Sortase A Inhibitors to Counteract Gram-Positive Bacterial Biofilms

Maria Valeria Raimondi; Roberta Listro; Maria Grazia Cusimano; Mery La Franca; Teresa Faddetta; Giuseppe Gallo; Domenico Schillaci; Simona Collina; Ainars Leonchiks; Giampaolo Barone

doi:10.3390/proceedings2019022023

Proceedings (Aug 2019)

Novel Sortase A Inhibitors to Counteract Gram-Positive Bacterial Biofilms

Maria Valeria Raimondi,
Roberta Listro,
Maria Grazia Cusimano,
Mery La Franca,
Teresa Faddetta,
Giuseppe Gallo,
Domenico Schillaci,
Simona Collina,
Ainars Leonchiks,
Giampaolo Barone

Affiliations

Maria Valeria Raimondi: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, (STEBICEF), University of Palermo, via Archirafi 32, 90123 Palermo, Italy
Roberta Listro: Drug Sciences Department, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, via Taramelli 12, 27100 Pavia, Italy
Maria Grazia Cusimano: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, (STEBICEF), University of Palermo, via Archirafi 32, 90123 Palermo, Italy
Mery La Franca: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, (STEBICEF), University of Palermo, via Archirafi 32, 90123 Palermo, Italy
Teresa Faddetta: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, (STEBICEF), University of Palermo, via Archirafi 32, 90123 Palermo, Italy
Giuseppe Gallo: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, (STEBICEF), University of Palermo, via Archirafi 32, 90123 Palermo, Italy
Domenico Schillaci: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, (STEBICEF), University of Palermo, via Archirafi 32, 90123 Palermo, Italy
Simona Collina: Drug Sciences Department, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, via Taramelli 12, 27100 Pavia, Italy
Ainars Leonchiks: APP Latvian Biomedical Research and Study Centre (BMC), Rātsupītes iela 1, LV-1067 Rīga, Latvia
Giampaolo Barone: Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, (STEBICEF), University of Palermo, via Archirafi 32, 90123 Palermo, Italy

DOI: https://doi.org/10.3390/proceedings2019022023
Journal volume & issue: Vol. 22, no. 1
p. 23

Abstract

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Sortase A (SrtA) is a membrane enzyme responsible for the covalent anchoring of surface proteins on the cell wall of Gram-positive bacteria. [...]

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Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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