Nature Communications (Sep 2018)

Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection

  • Tao Zuo,
  • Sunny H. Wong,
  • Chun Pan Cheung,
  • Kelvin Lam,
  • Rashid Lui,
  • Kitty Cheung,
  • Fen Zhang,
  • Whitney Tang,
  • Jessica Y. L. Ching,
  • Justin C. Y. Wu,
  • Paul K. S. Chan,
  • Joseph J. Y. Sung,
  • Jun Yu,
  • Francis K. L. Chan,
  • Siew C. Ng

DOI
https://doi.org/10.1038/s41467-018-06103-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Fecal microbiota transplantation (FMT) is effective in treating recurrent Clostridium difficile infection (CDI). Here, the authors show that the composition of the gut fungal microbiota of donors and recipients, and especially the abundance of Candida, correlates with FMT outcome in CDI patients.