Nature Communications (Apr 2022)
Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts
- Rebecca Caeser,
- Jacklynn V. Egger,
- Shweta Chavan,
- Nicholas D. Socci,
- Caitlin Byrne Jones,
- Faruk Erdem Kombak,
- Marina Asher,
- Michael H. Roehrl,
- Nisargbhai S. Shah,
- Viola Allaj,
- Parvathy Manoj,
- Sam E. Tischfield,
- Amanda Kulick,
- Maximiliano Meneses,
- Christine A. Iacobuzio-Donahue,
- W. Victoria Lai,
- Umeshkumar Bhanot,
- Marina K. Baine,
- Natasha Rekhtman,
- Travis J. Hollmann,
- Elisa de Stanchina,
- John T. Poirier,
- Charles M. Rudin,
- Triparna Sen
Affiliations
- Rebecca Caeser
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Jacklynn V. Egger
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Shweta Chavan
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Nicholas D. Socci
- Bioinformatics Core, Memorial Sloan Kettering Cancer Center
- Caitlin Byrne Jones
- Bioinformatics Core, Memorial Sloan Kettering Cancer Center
- Faruk Erdem Kombak
- Precision Pathology Center, Memorial Sloan Kettering Cancer Center
- Marina Asher
- Precision Pathology Center, Memorial Sloan Kettering Cancer Center
- Michael H. Roehrl
- Precision Pathology Center, Memorial Sloan Kettering Cancer Center
- Nisargbhai S. Shah
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Viola Allaj
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Parvathy Manoj
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Sam E. Tischfield
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
- Amanda Kulick
- Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center
- Maximiliano Meneses
- Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center
- Christine A. Iacobuzio-Donahue
- Precision Pathology Center, Memorial Sloan Kettering Cancer Center
- W. Victoria Lai
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Umeshkumar Bhanot
- Precision Pathology Center, Memorial Sloan Kettering Cancer Center
- Marina K. Baine
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Natasha Rekhtman
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Travis J. Hollmann
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Elisa de Stanchina
- Antitumor Assessment Core Facility, Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center
- John T. Poirier
- Perlmutter Cancer Center, New York University Langone Health
- Charles M. Rudin
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Triparna Sen
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-022-29794-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Creating accurate models of small cell lung cancer is essential to ensure the clinical relevance of results. Here, the authors create patient derived xenograft models from 33 patients and show, through multi-omics sequencing, that these models retain the primary features of the original.
