HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma

Hiroo Katsuya; Hideaki Nakamura; Aya Maeda; Keitaro Ishii; Toshiaki Nagaie; Haruhiko Sano; Haruna Sano; Hidekazu Itamura; Sho Okamoto; Toshihiko Ando; Toshiki Watanabe; Kaoru Uchimaru; Yorifumi Satou; Eisaburo Sueoka; Shinya Kimura

doi:10.1002/jha2.725

eJHaem (Aug 2023)

HTLV‐1 cell‐free DNA in plasma as a potential biomarker in HTLV‐1 carriers and adult T‐cell leukemia‐lymphoma

Hiroo Katsuya,
Hideaki Nakamura,
Aya Maeda,
Keitaro Ishii,
Toshiaki Nagaie,
Haruhiko Sano,
Haruna Sano,
Hidekazu Itamura,
Sho Okamoto,
Toshihiko Ando,
Toshiki Watanabe,
Kaoru Uchimaru,
Yorifumi Satou,
Eisaburo Sueoka,
Shinya Kimura

Affiliations

Hiroo Katsuya: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Hideaki Nakamura: Department of Transfusion Medicine Saga University Hospital Saga Japan
Aya Maeda: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Keitaro Ishii: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Toshiaki Nagaie: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Haruhiko Sano: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Haruna Sano: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Hidekazu Itamura: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Sho Okamoto: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Toshihiko Ando: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan
Toshiki Watanabe: Department of Practical Management of Medical Information Graduate School of Medicine St. Marianna University Kawasaki Japan
Kaoru Uchimaru: Laboratories of Tumor Cell Biology Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan
Yorifumi Satou: Division of Genomics and Transcriptomics Joint Research Center for Human Retrovirus Infection Kumamoto University Kumamoto Japan
Eisaburo Sueoka: Department of Clinical Laboratory Medicine Faculty of Medicine Saga University Saga Japan
Shinya Kimura: Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan

DOI: https://doi.org/10.1002/jha2.725
Journal volume & issue: Vol. 4, no. 3
pp. 733 – 737

Abstract

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Abstract Viral cell‐free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus‐associated tumors. We investigated whether the amount of cfDNA of human T‐cell leukemia virus type 1 (HTLV‐1) correlates with disease state in adult T‐cell leukemia‐lymphoma (ATL). HTLV‐1 cfDNA in aggressive ATL was significantly higher than that in indolent ATL and asymptomatic carriers. Notably, patients with lymphoma type represented higher HTLV‐1 cfDNA amount than chronic and smoldering subtypes, though they had no abnormal lymphocytes in the peripheral blood. HTLV‐1 cfDNA can be a universal biomarker that reflects the expansion of ATL clones.

Published in eJHaem

ISSN: 2688-6146 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://onlinelibrary.wiley.com/journal/26886146

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