Nature Communications (May 2020)
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
- Aruna Marchetto,
- Shunya Ohmura,
- Martin F. Orth,
- Maximilian M. L. Knott,
- Maria V. Colombo,
- Chiara Arrigoni,
- Victor Bardinet,
- David Saucier,
- Fabienne S. Wehweck,
- Jing Li,
- Stefanie Stein,
- Julia S. Gerke,
- Michaela C. Baldauf,
- Julian Musa,
- Marlene Dallmayer,
- Laura Romero-Pérez,
- Tilman L. B. Hölting,
- James F. Amatruda,
- Andrea Cossarizza,
- Anton G. Henssen,
- Thomas Kirchner,
- Matteo Moretti,
- Florencia Cidre-Aranaz,
- Giuseppina Sannino,
- Thomas G. P. Grünewald
Affiliations
- Aruna Marchetto
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Shunya Ohmura
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Martin F. Orth
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Maximilian M. L. Knott
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Maria V. Colombo
- Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC)
- Chiara Arrigoni
- Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC)
- Victor Bardinet
- Department of Pediatrics, Division of Oncology and Hematology, Charité Berlin
- David Saucier
- Department of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center and Children’s Medical Center
- Fabienne S. Wehweck
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Jing Li
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Stefanie Stein
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Julia S. Gerke
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Michaela C. Baldauf
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Julian Musa
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Marlene Dallmayer
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Laura Romero-Pérez
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Tilman L. B. Hölting
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- James F. Amatruda
- Department of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center and Children’s Medical Center
- Andrea Cossarizza
- Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine
- Anton G. Henssen
- Department of Pediatrics, Division of Oncology and Hematology, Charité Berlin
- Thomas Kirchner
- Institute of Pathology, Faculty of Medicine, LMU Munich
- Matteo Moretti
- Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC)
- Florencia Cidre-Aranaz
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Giuseppina Sannino
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Thomas G. P. Grünewald
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- DOI
- https://doi.org/10.1038/s41467-020-16244-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Ewing sarcoma is characterized by the fusion of EWSR1 and FLI1. Here, the authors show that EWSR1-FLI1 increases the activity of the developmental transcription factor SOX6, which promotes tumor growth but also increases sensitivity to oxidative stress.
