Nature Communications (Dec 2018)
Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
- Arianna Calcinotto,
- Arianna Brevi,
- Marta Chesi,
- Roberto Ferrarese,
- Laura Garcia Perez,
- Matteo Grioni,
- Shaji Kumar,
- Victoria M. Garbitt,
- Meaghen E. Sharik,
- Kimberly J. Henderson,
- Giovanni Tonon,
- Michio Tomura,
- Yoshihiro Miwa,
- Enric Esplugues,
- Richard A. Flavell,
- Samuel Huber,
- Filippo Canducci,
- Vincent S. Rajkumar,
- P. Leif Bergsagel,
- Matteo Bellone
Affiliations
- Arianna Calcinotto
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute
- Arianna Brevi
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute
- Marta Chesi
- Comprehensive Cancer Center, Mayo Clinic Arizona
- Roberto Ferrarese
- Laboratory of Microbiology, IRCCS San Raffaele Scientific Institute
- Laura Garcia Perez
- Molekulare Immunologie und Gastroenterologie, Universitätsklinikum Hamburg–Eppendorf
- Matteo Grioni
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute
- Shaji Kumar
- Division of Hematology, Mayo Clinic Rochester
- Victoria M. Garbitt
- Comprehensive Cancer Center, Mayo Clinic Arizona
- Meaghen E. Sharik
- Comprehensive Cancer Center, Mayo Clinic Arizona
- Kimberly J. Henderson
- Division of Hematology, Mayo Clinic Rochester
- Giovanni Tonon
- Division of Molecular Oncology, IRCCS San Raffaele Scientific Institute
- Michio Tomura
- Faculty of Pharmacy, Osaka Ohtani University
- Yoshihiro Miwa
- University of Tsukuba
- Enric Esplugues
- Department of Immunobiology, School of Medicine, and Howard Hughes Medical Institute Yale University
- Richard A. Flavell
- Department of Immunobiology, School of Medicine, and Howard Hughes Medical Institute Yale University
- Samuel Huber
- Molekulare Immunologie und Gastroenterologie, Universitätsklinikum Hamburg–Eppendorf
- Filippo Canducci
- Laboratory of Microbiology, IRCCS San Raffaele Scientific Institute
- Vincent S. Rajkumar
- Division of Hematology, Mayo Clinic Rochester
- P. Leif Bergsagel
- Comprehensive Cancer Center, Mayo Clinic Arizona
- Matteo Bellone
- Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute
- DOI
- https://doi.org/10.1038/s41467-018-07305-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The mechanisms through which gut microbiota affect extramucosal tumors are poorly understood. Here the authors show that the gut microbiota promotes multiple myeloma by inducing differentiation and migration of Th17 cells in the bone marrow resulting also in increased recruitment of pro-tumorigenic eosinophils.
