Heteronuclear Cross-Relaxation under Dynamic Nuclear Polarization in Nicotine and Caffeine

V. Aladin; P. A. Trenkler; B. Corzilius; Ausrine Bartasyte

doi:10.1017/exp.2020.17

Experimental Results (Jan 2020)

Heteronuclear Cross-Relaxation under Dynamic Nuclear Polarization in Nicotine and Caffeine

V. Aladin,
P. A. Trenkler,
B. Corzilius,
Ausrine Bartasyte

Affiliations

V. Aladin: Institute of Chemistry, University of Rostock, Albert-Einstein-Straße 3a, 18059Rostock, Germany Department Life, Light & Matter, University of Rostock, Albert-Einstein-Straße 25, 18059Rostock, Germany Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 7, 60438Frankfurt, Germany Institute of Biophysical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438Frankfurt, Germany
P. A. Trenkler: Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 7, 60438Frankfurt, Germany
B. Corzilius: ORCiD; Institute of Chemistry, University of Rostock, Albert-Einstein-Straße 3a, 18059Rostock, Germany Department Life, Light & Matter, University of Rostock, Albert-Einstein-Straße 25, 18059Rostock, Germany Institute of Physical and Theoretical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 7, 60438Frankfurt, Germany Institute of Biophysical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438Frankfurt, Germany
Ausrine Bartasyte: Burgundy Franche-Comté University, FEMTO-ST Institute, 26 rue de l’Epitaphe, Besançon, France, 25030

DOI: https://doi.org/10.1017/exp.2020.17
Journal volume & issue: Vol. 1

Abstract

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Dynamic nuclear polarization (DNP) is a technique in magic-angle spinning (MAS) nuclear magnetic resonance (NMR) which leads to sensitivity enhancement and helps to overcome the issue of low polarization in detected nuclei. Recent research showed, that methyl groups, which show active reorientation dynamics and cause heteronuclear cross relaxation at typical DNP temperatures around 100 K, may be used as a pinpoint source of polarization for selective and site-specific probing. In this study, we investigated the cross-relaxation behavior of methyl groups in nicotine and caffeine under DNP. These effects could be useful for investigating receptor/ligand binding.

Published in Experimental Results

ISSN: 2516-712X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Technology; Medicine; Science
Website: https://www.cambridge.org/core/journals/experimental-results

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