International Journal of General Medicine (Dec 2023)

Coagulation Parameters in Post-Covid-19 Condition in Relation to Various Titers of Anti-SARS-CoV-2 IgG in Blood Plasma

  • Strubchevska K,
  • Rachkovska A,
  • Krenytska D,
  • Karbovskyy V,
  • Kozyk M,
  • Secor B,
  • Raksha N,
  • Vovk T,
  • Savchuk O,
  • Falalyeyeva T,
  • Kaminsky R,
  • Ostapchenko L

Journal volume & issue
Vol. Volume 16
pp. 6127 – 6135

Abstract

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Kateryna Strubchevska,1 Antonina Rachkovska,2 Daryna Krenytska,2 Vitalii Karbovskyy,3 Marko Kozyk,1 Benjamin Secor,4 Nataliia Raksha,2 Tetiana Vovk,2 Olexii Savchuk,2 Tetyana Falalyeyeva,2 Rostyslav Kaminsky,5 Liudmyla Ostapchenko2 1Department of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA; 2Department of Internal Medicine, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; 3Department of Internal Medicine, LLS Biopharma-Plasa, Kyiv, Ukraine; 4Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Auburn Hills, MI, USA; 5Department Educational-Scientific Center ”Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Kyiv, UkraineCorrespondence: Marko Kozyk, 3601 W 13 Mile Road, Royal Oak, MI, 48073, Tel +1-305-773-5089, Email [email protected] and Objectives: Post-COVID-19 condition is thought to affect 10– 20% of people at least 3 months after a diagnosis of COVID-19 and two months of symptoms. Post-COVID-19 condition presents itself with many clinical effects with varying degrees of severity ranging from a mild cough to a life-threatening coagulopathy. Our study aimed to identify a relationship between the titers of anti-SARS-CoV-2 IgG and anticoagulation parameters: antithrombin III (ATIII), protein C (PC) and thrombomodulin (TM).Materials and Methods: Blood plasma was collected from healthy donors aged 25– 45 who had recovered from COVID-19 3– 6 months ago and their titers of anti-SARS-CoV-2 IgG and ATIII, PC, and TM were measured.Results: We found that concentrations and activities of key anticoagulation parameters (ATIII, PC, and TM) measured in donor plasma during the post-COVID-19 varied in relation to the titers of anti-SARS-CoV-2 IgG.Conclusion: While we identified a dysfunction of anticoagulation parameters in patients with post-COVID-19, we aim to explore the subpopulation antibody IgG fraction directly using in vivo and in vitro experiments with the possibility to contribute to the development of treatment options for post-COVID-19 conditions.Keywords: long-COVID, antithrombin III, thrombomodulin, protein C

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