Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

Ya-Sai Sun; Zi-Wei Wang; Zhe Gao; Wen Zhao; Kiran Thakur; Qian Zhong; Zhao-Jun Wei

Current Research in Food Science (Jan 2022)

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

Ya-Sai Sun,
Zi-Wei Wang,
Zhe Gao,
Wen Zhao,
Kiran Thakur,
Qian Zhong,
Zhao-Jun Wei

Affiliations

Ya-Sai Sun: College of Food Science and Technology, Agricultural University of Hebei, Baoding, 071001, PR China; School of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, PR China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China
Zi-Wei Wang: College of Food Science and Technology, Agricultural University of Hebei, Baoding, 071001, PR China
Zhe Gao: College of Food Science and Technology, Agricultural University of Hebei, Baoding, 071001, PR China
Wen Zhao: College of Food Science and Technology, Agricultural University of Hebei, Baoding, 071001, PR China
Kiran Thakur: School of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, PR China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China
Qian Zhong: School of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, PR China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China
Zhao-Jun Wei: School of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, PR China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China; Corresponding author. School of Biological Science and Engineering, North Minzu University, Yinchuan, 750021, PR China.

Journal volume & issue: Vol. 5
pp. 904 – 917

Abstract

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In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) and death receptor (Caspase 8-Caspase 3) pathways. Meanwhile, it was found that HPOE aggravated HCT116 cells death through lysosomal vacuolation, which was verified by inhibitor/activator of P53-ILC3 signaling pathway. Taken together, HPOE exerted anticancer effects which lays the foundation for the development of functional foods for clinical colon cancer patients.

Published in Current Research in Food Science

ISSN: 2665-9271 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply; Technology: Chemical technology: Food processing and manufacture
Website: https://www.journals.elsevier.com/current-research-in-food-science

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