Bioactive Materials Facilitating Targeted Local Modulation of Inflammation

Richard P. Tan, MSc; Alex H.P. Chan, BSc; Simon Wei, PhD; Miguel Santos, PhD; Bob S.L. Lee, MSc; Elysse C. Filipe, PhD; Behnam Akhavan, PhD; Marcela M. Bilek, PhD, MBA; Martin K.C. Ng, MBBS, PhD; Yin Xiao, PhD; Steven G. Wise, PhD

JACC: Basic to Translational Science (Feb 2019)

Bioactive Materials Facilitating Targeted Local Modulation of Inflammation

Richard P. Tan, MSc,
Alex H.P. Chan, BSc,
Simon Wei, PhD,
Miguel Santos, PhD,
Bob S.L. Lee, MSc,
Elysse C. Filipe, PhD,
Behnam Akhavan, PhD,
Marcela M. Bilek, PhD, MBA,
Martin K.C. Ng, MBBS, PhD,
Yin Xiao, PhD,
Steven G. Wise, PhD

Affiliations

Richard P. Tan, MSc: Heart Research Institute, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; Address for correspondence: Mr. Richard P. Tan, Applied Materials Group, The Heart Research Institute, 7 Eliza Street, Newtown NSW 2042, Australia.
Alex H.P. Chan, BSc: Heart Research Institute, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Simon Wei, PhD: Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia
Miguel Santos, PhD: Heart Research Institute, Sydney, New South Wales, Australia; School of Physics, University of Sydney, Sydney, New South Wales, Australia
Bob S.L. Lee, MSc: Heart Research Institute, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Elysse C. Filipe, PhD: Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; Garvan Institute of Medical Research, Cancer Division, Sydney, New South Wales, Australia
Behnam Akhavan, PhD: Heart Research Institute, Sydney, New South Wales, Australia; School of Physics, University of Sydney, Sydney, New South Wales, Australia; School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, New South Wales, Australia
Marcela M. Bilek, PhD, MBA: School of Physics, University of Sydney, Sydney, New South Wales, Australia; School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; Sydney Nano Institute, University of Sydney, Sydney, New South Wales, Australia
Martin K.C. Ng, MBBS, PhD: Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Yin Xiao, PhD: Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia
Steven G. Wise, PhD: Heart Research Institute, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia

Journal volume & issue: Vol. 4, no. 1
pp. 56 – 71

Abstract

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Summary: Cardiovascular disease is an inflammatory disorder that may benefit from appropriate modulation of inflammation. Systemic treatments lower cardiac events but have serious adverse effects. Localized modulation of inflammation in current standard treatments such as bypass grafting may more effectively treat CAD. The present study investigated a bioactive vascular graft coated with the macrophage polarizing cytokine interleukin-4. These grafts repolarize macrophages to anti-inflammatory phenotypes, leading to modulation of the pro-inflammatory microenvironment and ultimately to a reduction of foreign body encapsulation and inhibition of neointimal hyperplasia development. These resulting functional improvements have significant implications for the next generation of synthetic vascular grafts. Key Words: covalent biomolecule immobilization, inflammation, interleukin-4, neointimal hyperplasia, plasma-based ion implantation, radical functionalized surface, vascular graft

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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