Spinal Cord Injury Changes the Structure and Functional Potential of Gut Bacterial and Viral Communities

Jingjie Du; Ahmed A. Zayed; Kristina A. Kigerl; Kylie Zane; Matthew B. Sullivan; Phillip G. Popovich

doi:10.1128/mSystems.01356-20

mSystems (Jun 2021)

Spinal Cord Injury Changes the Structure and Functional Potential of Gut Bacterial and Viral Communities

Jingjie Du,
Ahmed A. Zayed,
Kristina A. Kigerl,
Kylie Zane,
Matthew B. Sullivan,
Phillip G. Popovich

Affiliations

Jingjie Du: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
Ahmed A. Zayed: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
Kristina A. Kigerl: ORCiD; Department of Neuroscience, The Ohio State University College of Medicine, Columbus, Ohio, USA
Kylie Zane: Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, Ohio, USA
Matthew B. Sullivan: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
Phillip G. Popovich: ORCiD; Department of Neuroscience, The Ohio State University College of Medicine, Columbus, Ohio, USA

DOI: https://doi.org/10.1128/mSystems.01356-20
Journal volume & issue: Vol. 6, no. 3

Abstract

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To our knowledge, this is the first article to apply metagenomics to characterize changes in gut microbial population dynamics caused by a clinically relevant model of central nervous system (CNS) trauma. It also utilizes the most current approaches in genome-resolved metagenomics and viromics to maximize the biological inferences that can be made from these data.

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

About the journal